The construction of Yakou shipping hub project affect the hydrodynamic characteristics of the middle and lower reaches of the Han River, and lead to changes in river water quality. By comparing three different scenarios: before the completion operation, after the completion operation, and the whole completion and operation of the midle and lower reaches of the Han River, the one-dimensional hydrodynamic and water quality model was used to simulate the hydrodynamic and water environment of the upstream and downstream of Yakou Shipping hub project, and the river eutrophication level under each scenario was evaluated according to the comprehensive nutrient state index. The results showed that there is no obvious change in the flow rate of each river section after the completion of the Yakou shipping hub. The water level of the dam was increased and the flow rate was decreased. After the completion of all the water conservancy hubs in the middle and lower reaches of the Han River, the discharge of each reach was decreased slightly, which has little influence on the water level of the main stream in the middle and lower reaches of the Han River. The level of chlorophyll a, total nitrogen, total phosphorus and CODMn in the upper and lower reaches of Yakou Dam increased with the completion and operation of Yakou shipping hub. The increase in non-flood season was greater than that in flood season.