The science of mental health factors confounding diagnostics in dementia has longstanding history in the scientific literature, with primary focus being on depressive cognitive disorders, formerly referred to as “pseudodementia.” Within this realm, depressive cognitive disorders (DCDs) reflect cognitive symptoms that may mimic symptoms of dementia. Understanding the presentation of cognitive symptoms within the context of depressive symptoms as individuals age, along with other mental health factors, is critical to accurate diagnostics and management of dementia.