In this chapter, we will review the epidemiology of diverticular disease, tracing it from a historical perspective to contemporary global patterns. Our analysis will encompass age and gender distribution, the burden and economic cost of the disease, and the effectiveness of global strategies for prevention and management. We will also delve into current trends and future predictions, culminating in a discussion on future directions in research and policy. This comprehensive exploration will not only provide a global overview but also highlight the personal impact of diverticular disease, leading to a deeper understanding crucial for shaping future healthcare strategies.