The importance of change and transformation in chemistry. The creation of value by the manipulation of existing material and the creation of novel and new substances.The building of metabolic iterations and relationships to create a deeper understanding. The development of contacts between Norfolk and Northern Europe through trade routes and the exchange of technical and scientific knowledge. The importance of centres of excellence such as Leiden to the acquisition of knowledge. The shortage of labour as a consequence of outbreaks of plague and wars. The movement of second and third generation immigrants to study at European universities. The continuation of macro weaving methodologies (textiles) to produce Covalent Organic Frameworks (COFs) with distinct molecular properties. The acquisition of knowledge about biological manipulation and the development of synthetic biology – engineering applied to biology. The increased understanding of macromolecular events such as crop rotation in the context of molecular and micrological interactions. The substantial importance of immigration and the two way flow of people, skills and knowledge between individuals, institutions and communities.