Spirit-children are a symbolic manifestation of the political, as their exceptionality illuminates foundational political concepts, like humanness and community. This chapter explores the nexus between the phenomenon of spirit-children in Guinea-Bissau, locally known as criança-irân, and their relevance for political analysis. It situates the debate at the intersection of political theory, African (political) philosophy, and comparative political theory in order to define and discuss political humanness. Political humanness represents the central concepts of this chapter, and it steers the analysis of the post-colonial political spaces in Guinea-Bissau. The notion of political humanness denotes the characterisation of human life as a specifically human and human-made mode of living (Agamben, 1995). This understanding creates the distinction between political and bare existence, taking human characteristics, such as reasoning and language, as enabling bases. The normative and ontological content of political humanness is juxtaposed with competing notions, such as the ethical and performative idea of personhood developed in African philosophy (Gyekye, 1997; Matolino, 2018; Menkiti, 2004). This exposition makes clear the significance of conceptualising humanness as part of political thought. As the latter is an unavoidable component of all human societies, the diversity of its configurations should be accounted for and reflected in political ideas. The criança-irân case exemplifies this diversity because it dares to disagree from integrating all Homo sapiens in the category of humans.