The clinical year of Physician Assistant/Associate (PA) education represents a transformative phase, bridging classroom learning with real-world patient care. This chapter explores the structure and expectations of clinical rotations and provides strategies for success, emphasizing professionalism as a cornerstone. Core rotations include Internal Medicine, Family Medicine, Pediatrics, Women’s Health (prenatal care and gynecology), Surgery, Behavioral Health, and Emergency Medicine, with elective opportunities in specialized fields, including but not limited to Cardiology, Pulmonology, Endocrinology, Dermatology, etc. Goals of each rotation include improving diagnostic acumen, enhancing patient communication, and demonstrating increasing autonomy. The professionalism component—defined by ethical conduct, accountability, and respect—plays a critical role in shaping patient outcomes and fostering interprofessional collaboration. Surgical rotations, among the most demanding experiences, require mastery of technical skills, sterile technique, and effective communication under high-pressure conditions. Strategies for success include thorough preparation, punctuality, proactive learning, and maintaining a positive mindset. Practical tips, such as reviewing surgical cases in advance, understanding team roles, and adhering to professional attire standards, are highlighted. Reflection and feedback are encouraged to foster continuous improvement. Ultimately, the clinical year equips PA students with competencies, developed by the American Academy of Physician Associates (AAPA), essential for lifelong practice integrating medical knowledge, technical proficiency, and professional behavior to deliver patient-centered care.