This chapter examines engineering culture from an anthropological perspective, analyzing how women and men in the profession confront their practices and habits within an interdisciplinary framework. It focuses on the machine as an artifact that transforms reality and, in doing so, requires human knowledge to account for the forms of life embedded in environments where artifacts interact with natural beings. Knowledge is shaped not only by scientific inquiry but also by personal and spontaneous contributions. The distinction between science and technology is explored through Claude Lévi-Strauss’s concept of “wild thought,” in which the “do-it-yourself” paradigm acquires particular significance. The metaphor of life on a space station encapsulates many of the constraints affecting engineering practice. As Samantha Harvey suggests in her novel Orbital, even within highly technological spacecraft environments, women and men remain fundamentally human.