Invasive Blood Pressure (IBP) is monitored by multimodule cardiac monitor. Equipment’s needed for monitoring IBP are arterial cannula, transducer, connecting wire of monitor, pressure bag to prevent arterial blood flow towards monitor and Normal saline with intravenous set. Complications occur if the patency of arterial canulation is not maintained. It shows false/wrong or no reading of arterial pressure on cardiac monitor this affect management of patient health condition. Quasi experimental pretest post-test one group design was used to determine the effect of interventions bundle to prevent complications of arterial cannulation. The reliability of tool was obtained by interrater method, where r value was 0.95. Non-probability purposive sampling technique was used to collect data from 30 samples. Data was collected by observing patients before (pretest) and after (Post-test) implementing interventions bundle. Paired t test and Fisher exact test used for analysis of data. T-values of test were 0.20, 1.17, 0.97,1.69, 1.56, 0.50, 2.93 and 3.21 at day1 morning & evening, day2 morning &evening, day3 morning & evening, day4 morning and evening. Corresponding p-values were small at time point’s day’s 4 morning and day4 evening (less than 0.05). Study accepts alternative hypothesis that interventions bundle is effective to prevent complications. This study concludes that a complication of arterial cannulation was decreased remarkably after implementation of interventions bundle. Interventions bundle is effective to prevent complications related to arterial cannulation.