This research presents the optimization of preparing hybrid polymer matrices composed of thermosetting and thermoplastic to address the resistance against impact forces and the mechanical characteristics of glass fiber reinforced polymer composites. A hybrid polymer composed of thermoplastic and thermoset was obtained at various ratios. A glass reinforcement in which glass microspheres were added at various percentages (0–10%) and a composite manufactured via hand layup, followed by compression molding with 4 layers of fiber, preserving a fiber volume fraction of 0.6. A mixture of hybrid polymers showing better properties against impact forces and mechanical features. Notably, 7–9% glass micro-spheres displayed an improved mechanical property, highlighting an increase in tensile strength at 7%. These results encourage the potential effect of hybrid matrices and micro-reinforcement in fabricating high-featured composites, considering high-impact engineering applications.