The global demand for liver grafts far exceeds the availability of donor livers, necessitating the use of livers from donation after circulatory death (DCD) despite their higher risk of complications. This chapter examines the current global state of DCD liver transplantation and the impact of the COVID-19 pandemic on transplant activity. There is significant variation between countries in the number of DCD liver transplants performed and the types of DCD donors utilized. Key contributing factors include the presence of an opt-out organ donation system, ICU capacity, the availability of traditional brain-dead donors, and cultural perspectives on withdrawing life-sustaining treatment. Additionally, the legalization of euthanasia and the extension of donor eligibility criteria have expanded the DCD donor pool. The increasing implementation of machine perfusion programs has facilitated viability assessment and prolonged preservation times for DCD livers. To meet the growing demand, transplant programs worldwide have adopted different strategies to safely utilize DCD livers as a viable donor source.

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Global State of DCD Liver Transplantation

  • Efrayim H. Küçükerbil,
  • Sophie P. Ciere,
  • Stefan H. Luijmes,
  • Zhiyong Guo,
  • Robert J. Porte,
  • Jeroen de Jonge

摘要

The global demand for liver grafts far exceeds the availability of donor livers, necessitating the use of livers from donation after circulatory death (DCD) despite their higher risk of complications. This chapter examines the current global state of DCD liver transplantation and the impact of the COVID-19 pandemic on transplant activity. There is significant variation between countries in the number of DCD liver transplants performed and the types of DCD donors utilized. Key contributing factors include the presence of an opt-out organ donation system, ICU capacity, the availability of traditional brain-dead donors, and cultural perspectives on withdrawing life-sustaining treatment. Additionally, the legalization of euthanasia and the extension of donor eligibility criteria have expanded the DCD donor pool. The increasing implementation of machine perfusion programs has facilitated viability assessment and prolonged preservation times for DCD livers. To meet the growing demand, transplant programs worldwide have adopted different strategies to safely utilize DCD livers as a viable donor source.