Since the advent of liver transplantation, optimal anesthesia care is necessary for positive perioperative outcomes. In the context of DCD liver transplantation, the anesthesiologist must understand the pathophysiology of these grafts and their predisposition to an increased incidence of intraoperative events such as post-reperfusion syndrome, which can affect both short- and long-term outcomes. Although there is minimal research in this area, it generally supports that DCD grafts have a higher incidence of intraoperative instability. However, advances in machine perfusion technology may reduce the risk of this perioperative outcome. Anesthesiologists should be aware of these implications and prepare accordingly for these cases, with considerations for advanced monitoring and alternative therapies for vasoplegia and cardiopulmonary collapse.