The history of slavery in the United States is examined in this chapter. From the beginning of the seventeenth century, millions of slaves contributed to establish colonies, and continued laboring in various regions of the Americas after independence. This chapter notes that the plight of enslaved people in America was worse than elsewhere like Greece, Rome, and Egypt. Slavery in the United States was especially brutal and dehumanizing. It was for life, and the children of enslaved people were destined to become the property of their owners, with no escape to freedom. The chapter looks into the economics, politics, and sociology of the institution of slavery. It probes the factors leading to the Civil War between the Union and the secessionist Confederate states. The main battles of the war are analyzed before the Union’s victory. The chapter notes how President Abraham Lincoln came to the point where he issued the Emancipation Proclamation granting freedom to enslaved people in the Confederate states.