Considering the growing environmental concern and limited natural resources, organizations have changed their way of doing business. Traditionally, the focus was solely on profit, but now organizations are creating, delivering and capturing value based on sustainable development principles while continuing to operate profitably. Addressing environmental, economic and social issues, companies are evolving their operational as well as manufacturing activities which contribute positively to our planet. Artificial intelligence (AI) is changing our world and lives, and so is our organizations. AI support organizations in maintaining zero waste practices by offering solutions to all challenges and promoting sustainable development. This chapter explores the role of AI in driving sustainable business models, addressing each of the challenges for promoting the concept of “zero waste intelligence”. This chapter begins with the introduction of sustainable business models and artificial intelligence with their definitions, followed by the pivotal role of AI in advancing sustainable business models through key mechanisms such as supply chain management, waste management and tracking, data analysis and data mining. Furthermore, the real-world case studies are also discussed in diverse sectors such as logistics, manufacturing, retailing and many more, emphasizing the solutions driven by AI, employed in reducing and managing waste, resource utilization and meeting sustainable development targets. Lastly, the chapter ends with the limitations and some future directions to the policymakers, marketers and businessman, guiding AI implementation in sustainable business practices. This chapter also offers ethical frameworks to ensure the role of AI in promoting true and long-term sustainability and highlights profitability and sustainability can exist together in modern business models.