Precision Agriculture (PA) has a short research and implementation history in Africa relative to other regions of the world. Uptake of PA technologies is also generally low and concentrated in a few countries. The low uptake of PA in Africa has been linked to various socio-economic, technological, and environmental constraints. These include low farm incomes, high capital cost of PA technologies, limited access to PA supportive technologies, small farm sizes, and undulating landscapes that limit the effective use of some PA supportive machinery. Despite these challenges and the current low uptake rate, PA remains highly relevant in farming systems in Africa. Increased adoption of PA can play a critical role in addressing a large part of the crop production intensification challenges related to sub-optimal crop and nutrient management practices, and high spatial variability. Indeed, the adoption of PA has been identified by the African Union as vital for the realization of an Africa free from hunger and poverty. The increasing availability of high-quality open access PA supporting data, plus the rapid advancements in affordable digital technologies present opportunities for addressing some of the challenges limiting uptake of PA in Africa. Recent continental level commitments by African Heads of State on leveraging digital technologies and on delivering targeted agronomic recommendations, and the establishment of an association with express mandate for mainstreaming PA related initiatives in Africa also provide the necessary political and institutional support required to facilitate the adoption of PA at scale. A nuanced approach that integrates ‘hard’ and ‘soft’ technologies tailored for specific socio-economic and environmental conditions will however be required for the effective mainstreaming of PA across Africa, and for the realization of the suite of benefits associated with application of PA.