Given the climate change pressure on the cities, water infrastructure resilience is crucial in ensuring sustainable development. While there are known benefits to Nature-based Solutions (NbS), further research is needed to explore the multifunctionality of NbS and make them more desirable in urban planning. If cities are to become resilient, they need to approach an ecosystem-like dynamic of autopoiesis where the city can reconstitute its components in a balanced relation with its environment. This chapter explores how the NbS strategy of constructed wetlands can be planned in the city to induce a biomass yield that can supply the construction industry with the purpose of establishing a working framework for future work and research. This exploration is a multi-method abductive research approach that combines urban and architectural design methodology with water management science to explore how a different approach to urban planning could manifest if cities are to become resilient through self-making of building components. The chapter provides an experimental exploration of a spatial-temporal design strategy for how to plan and design a constructed wetland area for cultivating materials, increasing human livability, increasing biodiversity, other cultivation etc. Said experiment allows the development of a framework from which one can pursue the goals of Urban Autopoiesis through wetlands design and planning. The framework indicates that the many parameters are systemically entangled, and much focus should be put on using such a framework and design prototyping to establish a dialog with relevant stakeholders through a systems thinking approach.