Ocular wound closure and tissue approximation require the use of suture materials and needles. Innumerable options for suture materials exist, making selection largely dependent on required suture characteristics and the ophthalmic surgeon’s preference. An understanding of the variety of suture materials and their respective uses is imperative for avoiding wound breakdown, leakage, and tissue injury This chapter details the classifications of suture materials and needles to provide an overview of those most used in ophthalmic surgery.