Industries have been revolutionized through the rapid proliferation of Internet of Things (IoT) and Cyber-Physical Systems (CPS), allowing for smart, interconnected devices. The proliferation of wireless communication technology, including ZigBee, LoRa and 5G use to drive growth is a substantial security and robustness challenge. The proposed Secure-by-Design framework is aimed at realizing the requirements of this environment, and include many levels protection will be there such as confidentiality through encryption; integrity can be assured using authentication and intrusion detection; availability guarantees are provided via reliability including retransmission & redundancy. In this paper we present such a framework to measure the security and reliability of CPS/IoT systems, in terms of slighting different wireless technologies under different attack scenarios. Experimental results indicate that even though the security implementations result in small performance degradation with respect to packet delivery and latency, these trade-offs are not significant enough to put a question mark on reliability of CPS applications. The planned framework exhibits strong resiliency against Denial-of-Service (DoS), spoofing and man-in-the-middle attacks and can help in enhancing security in resource-constrained environments.