Submerged aquatic macrophytes (SAMs), they offer an eco-friendly solution to address the growing issue of wastewater treatment. There are various methods in which SAMs help in detoxifying various kinds of wastewater, including residential, factory, and agricultural runoff. They do the same by the following processes: phytoremediation (plant-based pollution removal), nutrient removal, and enhancing the activity of beneficial microorganisms. SAMs work efficiently to absorb and utilize pollutants like nitrogen, phosphorus, and heavy metals, ensuring improved water quality and lowering high nutrient levels. The chapter elaborates on how the inclusion of SAMs in constructed wetlands can promote additional pollutant removal through the combination of plant uptake, microbial degradation, and solid settling. Though promising, the application of SAMs has problems such as seasonality changes, potential invasion, and ongoing management needs. The chapter indicates further study and the formulation of new management practices to reap most of the benefits of SAM utilization in wastewater treatment, noting the potential as an excellent complement or alternative to standard practices.