Intelligent active control systems that seek to mitigate seismic reactions have been developed as a result of the growing requirement to eliminate unwanted vibrations in structures. Peak inter-story drifts and total drift responses are two of the most important structural metrics because they affect building integrity, occupant safety, and possible damage reduction during earthquakes. Inter-story drift mitigation is therefore essential. Our study focuses on using a sophisticated neuro-controller-controlled Active Mass Damper (AMD) technology to dramatically lessen seismic impacts on a five-story structure. The AMD system’s performance is contrasted with that of a traditional Passive Tuned Mass Damper (TMD) system. According to simulations using historical earthquake data, such as the Northridge far-fault, Chi-Chi near-fault without pulse, and Loma Prieta near-fault with pulse. The neuro-controller-driven AMD system is more successful in reducing critical structural responses of peak and total inter-story drifts. These findings highlight the benefits of using intelligent control systems to improve a building’s seismic resistance.