This study employs qualitative comparative analysis to explore the configurational conditions for cross-cultural employees to achieve high levels of well-being in cross-linguistic and cultural environments. It identifies four pathways: Instrumental-Exposure, Instrumental-Integrative, Sensitive-Exposure, and Sensitive-Communicate. Using Chinese employees in Japan as the sample, the research reveals that the well-being of cross-cultural employees is not determined by a single condition, but by the synergistic or substitutive effects of different configurational conditions, with the level of intercultural sensitivity serving as the core boundary condition distinguishing these pathways. The findings contribute to a deeper understanding of how intercultural sensitivity, multilingual learning incentives, and intercultural communication dynamics jointly influence mental health outcomes in cross-cultural contexts. By examining these mechanisms, the research seeks to provide insights for cross-cultural management practices and talent development strategies in multinational organizations.