The Laguna Valle de Las Garzas in the Mexican Central Pacific is a system contiguous to the Port of Manzanillo, the most important commercial port in the country, where the pressures and environmental impacts caused by port-industrial and urban development are analyzed with respect to their relationship with compliance with environmental regulations. Using the Driver Pressure State Impact Response framework, relationships between pressures and ecological status were identified by monitoring physicochemical parameters vs Mexican environmental regulations, reaching the projection of scenarios in response to current and future conditions. The pressures identified are related to industrial activities and port services associated with its infrastructure and economic development, which between 1985 and 2022 caused a reduction of water reservoir (coastal lagoon) from 148 to 60.2 ha (59.3%), which is related to irregular urban growth and incompatible land uses. These generated alterations in its water quality that exceed the limits established in environmental regulations to the detriment of its ecosystem functions due to deficient governance that does not consider regional particularities and is incompatible at administrative scales. The best scenario promotes reversing its continuous deterioration by regulating industrial activities and urban growth that makes existing instruments and regulations effective for recovery and conservation purposes to achieve development in accordance with new international trends like blue economy. This work reflects the urgent need to conserve coastal environments due to the socio-environmental benefits they provide, since the consequences are reflected in the degradation of its environmental quality and in the increase in vulnerability for the city-port binomial.