This chapter applies previous empirical review, marine spatial planning and existing legislation to assess the far-reaching consequences of marine pollution on the blue economy. The emphasis is currently on a sustainable blue economy comprising fisheries and aquaculture, maritime transport, marine tourism and mining, renewable energy, and coastal estate development, which are threatened or jeopardized in varied ways by marine pollution. Its results realize both land-based and ocean-based sources of trash and chemical pollutants by anthropogenic operations, thereby disrupting the three pillars of a sustainable blue economy socially, economically, and environmentally. Despite this, there are still many challenges or barriers surrounding the sustainable blue economy including a lack of context-specific policies, regulations, strategies, and plans. Thus, the management and governance of a sustainable blue economy lies in constructive planning and policy implementation, which might underscore the effectiveness of existing institutional instruments. The chapter argues that “ecosystem-based marine spatial planning and legislation framework assessment” offers practical recommendations for the many problems facing marine pollution and its impacts on a sustainable blue economy. It also proffers insights or experiences from Namibia which provide indicators for planning and executing a harmonious balance between marine conservation and socio-economic development.