Fungal infections of the lacrimal system are relatively uncommon and affect the lacrimal ducts or structures associated with draining the tears. Fungal infections in this area can be caused by Candida spp. and Aspergillus spp. These fungal pathogens can invade the lacrimal system as a result of local trauma, surgery, or in individuals with immunodeficiency. Symptoms may include chronic watering of the eyes (epiphora), discharge from the lacrimal ducts, swelling, and conjunctivitis. Diagnostic procedures include a detailed examination of the eyes and surrounding structures, imaging tests, and taking samples to identify the specific fungus causing the infection. Treatment includes antifungal pharmacotherapy (eye drops, oral, or intravenous administration) and surgical interventions targeting the lacrimal system, depending on the severity and extent of the infection. This chapter discusses the etiologies, pathogenesis, clinical presentation, diagnosis, differential diagnosis, and treatment of fungal canaliculitis and dacryocystitis.