This study investigates the influence of engine position on the structural resistance of intercity buses during rollover events. Utilizing finite element method (FEM) simulations, two distinct bus configurations were analyzed: front-engine and rear-engine layouts. Both models adhered to international passive safety standards, specifically UNECE Regulation No. 66, ensuring a survival space free from structural intrusion. The simulation results revealed significant differences in deformation patterns based on engine location. Front-engine buses exhibited critical intrusion primarily in the initial frames, compromising occupant safety. In contrast, rear-engine buses dispersed rollover energy more effectively toward mid-sections without breaching the survival space. The front-engine configuration presented intrusions up to –38.1 mm, requiring reinforcement with high-strength materials or structural foam. Conversely, rear-engine configurations maintained safer distances, yet suggested reinforcement in mid-sections to guarantee compliance under extreme conditions. The research emphasizes the critical role engine placement plays in rollover safety and structural design. Recommendations derived from this analysis advocate integrating high-strength reinforcements tailored to engine location, enhancing overall bus crashworthiness. Ultimately, this study provides foundational insights essential for improving bus structural safety standards and reducing fatalities and injuries resulting from rollover accidents.