This extensive chapter explores current and emerging antioxidant therapeutic strategies for combating oxidative stress-related diseases. Comprehensive explanations have been provided regarding the contribution of oxidative stress in a variety of disorders, including diabetes, cancer, neurodegenerative problems, autoimmune disorders, and cardiovascular complications. The chapter highlights classes of antioxidants, their modes of action, and innovative delivery systems such as nanotechnology-based parenteral delivery, transdermal dosage forms, and inhalation methods have been thoroughly explained. Furthermore, recent clinical applications, ongoing research, and market trends in antioxidant therapeutics have been discussed. Novel strategies, including genomics and biomarker-based customized antioxidant therapy, are discussed, along with possible synergistic combination drug treatments. Moreover, the chapter also examines the future prospects, highlighting the potential of newly developed antioxidant compounds, targeted delivery technologies and stimuli-responsive antioxidant delivery systems. Overall, this chapter provides a comprehensive overview of the current state and future directions of antioxidant therapeutic strategies, emphasizing their potential in treating and preventing a wide range of diseases associated with oxidative stress. The incorporation of cutting edge drug delivery techniques and precision medicine strategies shows potential for enhancing the therapeutic impact and targeted action of antioxidant therapies in clinical applications.