Availability and accessibility to water is continuing as a burning issue in the modern world and is placed significantly in the UNDPs sustainable Development Goals (SDGs’). Water is a vital resource for all forms of life in every environment and groundwater is considered as a readily available source of freshwater. Effective groundwater potential zone mapping is crucial for water security, its management, planning and cumulatively for overall well-being of the ecosystem. Present study applied remote sensing, GIS and MCDM through the Analytical Hierarchy Process (AHP) to identify potential groundwater zones in the Dhasan River Basin, a semi-arid region of Bundelkhand, which supports millions of population in central India. The factors considered for identifying potential groundwater zones include slope, drainage density, lineament density, lithology, geomorphology, soil, rainfall and land-use/land-cover (LULC). Thematic layers for these factors were created and weights were assigned to identify groundwater potential zones, that were classified into four categories: very high (1.9%), high (24%), low (72.2%) and very low (1.9%) potential zones. Majority of the area of the basin consist of hard rock terrain formed by Archean, Mesoproterozoic, Precambrian and Cretaceous rocks with very low porosity and permeability, which has restricted the groundwater recharge and contribute to groundwater scarcity in the basin. These potential zones can be utilized for water resource planning in the region.