In the modern digital landscape, web applications are accessed from a multitude of devices, including smartphones, tablets, desktops, and emerging wearable technologies. This necessitates responsive user interfaces (UI) that can adapt seamlessly to different screen sizes, resolutions, and orientations, ensuring consistent usability and user satisfaction. Tailwind CSS, a utility-first CSS framework, combined with React, a component-based JavaScript library, provides developers with an efficient, scalable, and maintainable approach to building responsive full-stack applications. Tailwind CSS reduces development time by offering pre-defined utility classes for styling, responsive modifiers, and interactive states, while React’s reusable components and dynamic state management enable adaptive, interactive, and modular UI structures. This paper explores the methodologies, integration techniques, best practices, accessibility considerations, performance optimizations, testing strategies, challenges, and future trends in responsive full-stack development using Tailwind CSS and React.