Enhancing value in the management of osteogenesis imperfecta (OI) presents significant challenges due to the variability in disease presentation, making it difficult to standardize cost-effective care. However, this chapter highlights multiple methods to provide value-based care when treating fractures in the OI population. Decisions regarding fracture prevention and management should be made through a team-based, interdisciplinary approach, incorporating both pharmacologic and nonpharmacologic treatments tailored to the individual patient.