Subacute de Quervain’s thyroiditis is a self-limiting inflammatory condition of the thyroid gland that may last for a week to several months. It is the most common cause of “painful” thyroiditis and is most likely of post-viral origin. Characteristically, it has a tendency to recur. The gland is typically involved as a whole, and thyroidal radioactive iodine uptake (RAIU) is much depressed. Transient hyper-thyroxinemia, elevation of the serum thyroglobulin (Tg) concentration and the erythrocyte sedimentation rate (ESR), and sometimes the white cell count (WBC) during the early acute phase are characteristic if not pathognomonic. Characteristically, the patient has severe pain and extreme tenderness in the thyroid region. As the disease process subsides, transient hypothyroidism occurs in approximately 25% of the patients. Ultimately thyroid function returns to normal and permanent hypothyroidism occurs in less than 10% of the cases, and recurrence may be noted in approximately  4%. Subacute thyroiditis is usually self-limiting and, in some patients, no treatment is required. However, for many, some form of medical therapy is warranted to treat the symptoms of the disease until it resolves. Surgical intervention is not the primary treatment of SAT, but rarely this has been performed due to presence of indeterminate cytology on fine-needle aspiration (FNA) or due to severe pain. The incidence rate of SAT has maintained an upward trend in recent years. Recurrence and prolonged treatment time have become severe problems for the treatment of SAT.