This chapter examines the evolution of e-commerce within ophthalmology and healthcare, emphasizing how artificial intelligence (AI), big data analytics, and digital platforms are redefining medical service delivery, patient engagement, and healthcare accessibility. The analysis traces developments in healthcare e-commerce research from 1993 to 2024 through a bibliometric study using Scopus data analyzed with VOSviewer and Biblioshiny. The results reveal a marked increase in publications beginning in 2019, peaking in 2021 due to the COVID-19 pandemic’s acceleration of digital adoption. Key themes include the integration of AI, blockchain, and telemedicine technologies into healthcare marketplaces, as well as the emergence of cross-border e-commerce and virtual consultation platforms. China, the United States, and India lead global research output, reflecting robust investment in digital health ecosystems. While e-commerce innovations are improving access and operational efficiency, challenges persist in regulatory oversight, data security, and the control of counterfeit products. The chapter underscores the importance of sustainable, ethical, and patient-centered strategies for future development, positioning AI-driven e-commerce as a vital component of next-generation ophthalmic and healthcare delivery systems.