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Carbapenems are broad-spectrum β-lactam antibiotics effective against multidrug-resistant (MDR) pathogens, particularly in nosocomial infections. They bind to penicillin-binding proteins (PBPs) to inhibit cell wall synthesis, causing bacterial cell lysis. Meropenem is particularly efficacious in the treatment of MDR urinary tract infections (UTIs). Carbapenems face rising resistance; carbapenem-resistant Enterobacteriaceae (CPE) and Pseudomonas aeruginosa (CRPA) pose significant clinical challenges, particularly in healthcare settings with immunocompromised patients.

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Carbapenems

  • 章节

  • 发表日期：

    2026年

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  • Aayush Sinha

摘要

Carbapenems are broad-spectrum β-lactam antibiotics effective against multidrug-resistant (MDR) pathogens, particularly in nosocomial infections. They bind to penicillin-binding proteins (PBPs) to inhibit cell wall synthesis, causing bacterial cell lysis. Meropenem is particularly efficacious in the treatment of MDR urinary tract infections (UTIs). Carbapenems face rising resistance; carbapenem-resistant Enterobacteriaceae (CPE) and Pseudomonas aeruginosa (CRPA) pose significant clinical challenges, particularly in healthcare settings with immunocompromised patients.