Three-dimensional modeling is transforming how medicine is taught and practiced. Converting CT and MRI datasets into accurate digital or printed replicas enables clinicians, trainees, and patients to visualize complex anatomy and pathology beyond the limits of two-dimensional images. For medical students and residents, 3D models support spatial understanding, deliberate practice, and improve procedural training by allowing repeated manipulation of anatomy and rehearsal of procedures without specimen degradation. Integration with virtual, augmented, and mixed reality extends learning to immersive team training and decision making. In this chapter, we outlined the technical workflow from acquisition to segmentation to design and fabrication; and showed how these steps map to curriculum objectives and competency-based assessment. Clinically, patient specific models facilitate preoperative planning, improve prosthetic and implant design, and enhance counseling by making pathology tangible for patients and families. We also address accuracy, privacy, cost, and regulatory considerations that influence adoption. 3D modeling serves as a bridge between education and precision medicine by linking clear learning objectives with measurable outcomes and by tailoring care to individual anatomy. The chapter provides educators and clinicians with a structured approach to integrate these tools into teaching and clinical practice.