This chapter examines the cultural and ideological dimensions of neo-colonial subjugation through the frameworks of post-colonial theory and critical religion studies, focusing on the enduring influence of Western religions and cultural hegemony in Africa. It argues that Christianity and Islam—instrumentalized during colonial rule—functioned not only as vehicles of spiritual expansion but also as ideological tools that dismantled indigenous cosmologies and legitimized imperial domination. Drawing on the works of Frantz Fanon, Ngũgĩ wa Thiong’o, John Mbiti, and Edward Said, the chapter interrogates the psychic dislocation produced by colonial alienation and the internalization of Eurocentric norms. Western curricula, missionary education, and media continue to propagate cultural hegemony by marginalizing African languages, religious systems, and aesthetic values. Yet, the chapter also highlights a rising wave of cultural resistance—from the revival of African spiritualities and indigenous languages to the use of digital platforms for epistemic revalorization. These efforts represent a growing movement toward cognitive decolonization as a critical complement to political and economic emancipation. Situating religion and culture within the matrix of neo-colonial power, the chapter argues that true liberation requires not only material autonomy but also the restoration of Africa’s epistemic sovereignty.