This work investigates the thermal properties of ZnO nanofluids for cooling computer processors. The study examined two volume fractions: a 0.25% addition of water-based ZnO nanofluid and a 0.5% addition for enhancing heat dissipation in a computer processor. The experimental setup utilized a commercially available liquid cooling system for a CPU. The present study measured key performance parameters at no-load and full-load conditions, including heat transfer rates, convective heat transfer coefficients, heat exchanger effectiveness, and CPU temperature. Improved results were noted with increased ZnO nanofluid concentration, leading to a significant enhancement in cooling performance. At concentrations of 0.25% and 0.5%, the heat transfer rates increased by 28.9% and 42.9%, respectively, compared to deionized water. Similarly, the CPU temperatures decreased by 13% at no-load and 9% at full-load. These results suggest that ZnO nanofluids have potential as coolants in high-performance computing device applications.