This article examines the use of design thinking to improve the use and accessibility of mathematical formulas in web-based lessons. The authors analyze some existing educational resources, web technologies related to mathematics, and the needs of various users, particularly students with disabilities, who require adapted interfaces when interacting with mathematical content. The main focus is on the user-centered approach, whereby defining the needs of different user groups and thinking innovatively, solutions are developed that make the mathematical content more understandable and motivate the application of the acquired knowledge. Practical examples and recommendations for integrating technologies such as MathML, tailored to the needs of people with disabilities, to create interactive and effective e-learning environments are presented. A structured model for describing mathematical formulas in web tutorials is developed and empirically validated. The model is based on design thinking, uses current technologies and conforms to new trends and recommendations for web design to achieve a higher degree of web accessibility and provide good visualization and accessibility to the formulas.