The convergence of artificial Intelligence (AI), and Blockchain technology is remodelling the healthcare enterprise into a paradigm shift. AI permits fitness offerings to analyse large records to make the right prognosis, to customize remedy and forecast analytics to optimize patient consequences. Concurrently, blockchain is a decentralized and relaxed community of medical facts dealing with that offers transparency and traceability and ensures the integrity of medical facts during all clinical techniques. The chapter elaborates how mixed technology is useful in combating such vital troubles as facts privateness, interoperability and medical device fraud. The improvements that might be most significant are AI-based totally robotic surgery, a blockchain-primarily based machine of affected person consent, and smart contracts in insurance and billing. The unification of AI with blockchain does not only optimize the clinical workflows, however it also puts a patient in greater manipulation of their health records. Moreover, those technologies have realistic programs that are proven via real-life case studies in the telemedicine, electronic health information (EHR), and drug supply chains spheres. The chapter also recalls the modern-day drawbacks and ethical troubles irrespective of their potentiality and proposes a manner to a hit implementation. Altogether, AI-based blockchain is a recent movement in healthcare innovation that is expected to ease medical services, improving their safety and customization.