This study introduces a mobility-aware spectrum handoff technique for cognitive radio systems that addresses the problem of spectrum scarcity in 6G-enabled vehicle networks. In contrast to previous studies, this work presents a novel integrated pool-based and cell-based spectrum handoff model designed for non-stationary cognitive users in heterogeneous spectrum settings. The study intends to offer a more thorough method of spectrum handoff in 6G-enabled vehicle networks by taking into account both centralized and ad-hoc network topologies within this integrated model. The primary motivation is to enhance spectrum efficiency and ensure seamless communication for vehicular applications by enabling cognitive users to dynamically access unused licensed spectrum while protecting primary users. Considering variables like primary user activity, cognitive user mobility, and different service time distributions, the suggested spectrum handoff technique is evaluated based on link maintenance probability and link failure probability. The results of simulations verify that the integrated handoff model is a good way to guarantee dependable connectivity for mobile cognitive users in 6G vehicle networks. Monte Carlo simulations are also used to confirm the analytical results’ accuracy.