Approaching the Nature Based Solutions (NBS) impact evaluation; to define the effectiveness of certain strategies and actions, it is fundamental to define a series of criteria and parameters (referred to sustainability topics) for which the specific NBS efficacy can be measured. In the paper, the authors face the example of an aquaponic system in the city of Stradella. Aquaponic is investigated as a NBS for improving urban food production using white water that usually, in Italy, is lost in the sewage system. A simulation model based on FAO (2014) is used to evaluate the technical performance, environmental advantages, economic feasibility, and some social consequences of a 100 m2 urban aquaponic system. According to the results, the system can produce food while using 95% less water than traditional agricultural practices and methods, and from the economic point of view the system has a payback period of 2.5 years. The findings suggest that aquaponics might be included into urban sustainability strategies to enhance food security, resource efficiency, and social resilience in smaller cities in Europe.