For deep wells, during the drilling of large-size boreholes in the upper part of ultra-deep wells, the drill bit breaks the rock to stimulate the drilling, and the wellhead drill string vibrates violently. In this paper, a self-rotation torsional vibration reduction stabilizer is proposed, and the strength of its key components is analyzed by finite element method. Based on Abaqus, a three-dimensional dynamic model of the drill string in the whole well section was established, and the influence of the self-rotating torsional vibration reduction stabilizer on the axial and lateral vibration of the drill string under different wellhead distances (10m, 50 m, 100 m, 200 m, 300 m) was studied. The results show that the self-rotation torsional vibration reduction stabilizer can effectively suppress the vibration transmission. As the distance from the wellhead increases, the axial and lateral vibration of the drill string gradually decreases. The vibration reduction of the stabilizer at different positions is as follows: when the distance from the wellhead is 10 m, 50 m, 100 m, 200 m and 300 m, the axial vibration is reduced by 12.50%, 25.00%, 34.38%, 36.80% and 39.30% respectively; the transverse vibration decreased by 12.07%, 18.97%, 34.48%, 36.20% and 37.70%, respectively. In addition, the vibration peak is also reduced. According to the comprehensive analysis, it is suggested that the vibration reduction effect is the best when the stabilizer is placed in the range of 200–300 m from the wellhead.