Physical exploration methods have become an important means and method for polymetallic mineral exploration, especially as the pace of polymetallic mineral exploration in China continues to accelerate, the comprehensive utilisation of physical exploration methods has put forward higher requirements. This study aims to explore the investigation and evaluation methods of polymetallic resources based on magneto electric comprehensive geophysical exploration technology. The study used a combination of on-site investigation and laboratory analysis to systematically analyze the characteristics and distribution patterns of polymetallic deposits in different geological environments. The study shows that the application of magneto-electric comprehensive physical exploration technology can reveal the whole picture of the magnetic field in the survey area; it can basically find out the electrical spreading characteristics of the profile, so as to infer the development of faults and rock strata, and provide a basis for the deployment of the next step of exploration work.