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Tl-201 is a low-energy potassium analogue. Before the introduction of Tc-99m-MIBI and Tc-99m-tetrafosmin, Tl-201 was used for myocardial perfusion scintigraphy. Like Tc-99-MIBI, it was also used for imaging tumours, especially parathyroid adenomas. The main use for Cr-51 was as the EDTA chelate for measuring GFR. It has historical interest for labelling erythrocytes and leucocytes for haematological applications. Ga-67, which binds to circulating transferrin following i.v. injection and circulates as a metal-protein complex, is a useful tracer for the investigation of fever of unknown origin but has been replaced by FDG PET/CT for this application. The complex diffuses across compromised vascular endothelium and binds to interstitial transferrin receptors.

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Radionuclides of Historical Interest

  • 章节

  • 发表日期：

    2026年

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  • Adrien Michael Peters,
  • Manuela Vadrucci

摘要

Tl-201 is a low-energy potassium analogue. Before the introduction of Tc-99m-MIBI and Tc-99m-tetrafosmin, Tl-201 was used for myocardial perfusion scintigraphy. Like Tc-99-MIBI, it was also used for imaging tumours, especially parathyroid adenomas. The main use for Cr-51 was as the EDTA chelate for measuring GFR. It has historical interest for labelling erythrocytes and leucocytes for haematological applications. Ga-67, which binds to circulating transferrin following i.v. injection and circulates as a metal-protein complex, is a useful tracer for the investigation of fever of unknown origin but has been replaced by FDG PET/CT for this application. The complex diffuses across compromised vascular endothelium and binds to interstitial transferrin receptors.