Black sexual minority men (SMM) experience disproportionate health inequities across chronic conditions such as diabetes, hypertension, cancer, and depression; however, practice guidelines remain dominated by biomedical or HIV-focused approaches. This narrow scope neglects broader social and structural contexts in which health is experienced, particularly at the intersections of race, sexuality, and personal history that shape Black SMM’s general relationships with prevention, healthcare, and treatment. Studies consistently show that Black SMM want healthcare that truly reflects what care should mean: relational, empathetic, and affirming, attuned to their lived experiences. There is also a need for ongoing support mechanisms that address not only disease management but the emotional, social, and structural dimensions of wellness across the life course for this group. Using the experiences of U.S. Black SMM as a conceptual and empirical backdrop, this chapter examines how these insights hold broader relevance for Black SMM globally, many of whom face similar systems of racialized and sexual marginalization within differing sociopolitical and health infrastructures. The chapter identifies gaps in current clinical and public health guidelines, particularly their limited attention to intersectionality, relational care, and social context. We offer recommendations for updating these frameworks to ensure greater cultural and clinical relevance, emphasizing models that integrate comprehensive care with empathy, trust, and sustained engagement. To demonstrate these principles in action, this chapter presents case studies applying nursing care models that demonstrate how theory-driven, community-informed approaches can be used to advance health equity. Collectively, these examples underscore the transformative potential of nursing frameworks to translate research into practice, redefining “care” not as a clinical encounter, but as an intentional, human-centered process capable of promoting holistic health and justice for Black SMM in the U.S. and globally.