Cyber-physical systems (CPS) blend physical elements with integrated computing capabilities across interconnected networks, facilitating data exchange for various functionalities. However, CPS often suffer from drawbacks associated with centralized architectures, leading to vulnerabilities in security, reliability, and privacy. Inadequate data protection mechanisms can further exacerbate these issues. Blockchain technology offers a decentralized solution, employing sophisticated encryption for data transmission without relying on centralized intermediaries for verification and certification. Integration of CPS with blockchain shows promising features, enhancing security and resistance to tampering and fraud. This chapter explores various blockchain technologies applied in CPS, emphasizing their advantages and deployment across diverse applications. Additionally, it examines ongoing research efforts aimed at addressing security concerns within CPS environments.