Infectious spondylodiscitis, the infection of the intervertebral disc and the contiguous vertebral bodies, must be managed in a multidisciplinary fashion, accounting for clinical findings, comprehensive imaging evaluation of the spine, and bacteriological sampling. Its treatment is usually medical with prolonged antibiotic therapy. However, in cases of failure of conservative management or complication onset, surgery can be indicated: laminectomy in case of neurological deficit and pedicle fixation in case of instability or kyphosis, and corpectomy for the most severe lytic lesions.