In this chapter, I systematically revisit the intricate interplay between philosophy and science in Jonas’s thought, focusing on the essential question of meaning. I emphasize the deep connection between the concepts of freedom and responsibility, which are critical to understanding human existence and its ethical implications. Jonas’s reflections, I argue, are crucial for contemporary philosophical debates, particularly those concerned with humanity’s responsibility toward life in an era of technological and ecological crisis. This makes Jonas’s thought especially pertinent today, offering valuable insights into the moral and philosophical challenges posed by climate change and environmental degradation.