Advancements in breast imaging and widespread screening have led to increased detection of non-palpable breast lesions, requiring precise localization and excision strategies. This chapter reviews the evolution of localization techniques, from traditional wire-guided approaches to the more recent innovations in wireless technologies. Wireless technologies are presented as transformative tools, offering enhanced precision, aesthetics, and surgical efficiency. This comprehensive overview underscores the importance of multidisciplinary planning and personalized localization strategies to achieve optimal oncologic and cosmetic outcomes.