This study aims to assess the effect of an eight-week aerobic exercise program on cardiovascular and metabolic health factors in sedentary women aged 30–45 years. Although being experimental in nature, the pre-test and post-test design here assess the changes in resting heart rate, total, HDL, and LDL-cholesterol after THE THERAPY. Results show a statistically significant decrease in resting heart rate (17.89%), which implies increased cardiac efficiency. In addition, the study reports a 24.48% decrease in the total cholesterol levels and 37.37% decrease in the LDL cholesterol levels, clearly confirming the efficacy of this type of training practice on the risk factors for cardiovascular diseases. Additionally, the HDL cholesterol levels were raised by 15.47%, highlighting the positive effect of aerobic capacity exercise on lipid metabolism and cardiovascular health protection. Results support by structured aerobic of program, as a non-drug to lipid profiles of subjects in general and the heart health. Data were analyzed from nearly 3800 Korean adults to look for associating factors such as aerobic exercise and routine lifestyle information that could link these with beneficial changes in the gut microbiome, leading to discoveries that could underpin cardiovascular and metabolic treatment strategies. 7,8 Future research is needed to evaluate long-term adaptations, the comparative effectiveness of exercise versus resistance training, and the role of exercise in altering pulmonary and/or dietary cholesterol levels, in order to provide a holistic perspective of exercise induced metabolic changes.