Purpose The aim of this study was to analyze the influence of a structured preventive training program on the improvement of agility and balance among genetically predisposed soccer players. As genetic variations found in COL1A1, COL5A1 and GDF5 are associated with an increased susceptibility to musculoskeletal injury, this study set out to test whether targeted neuromuscular training would attenuate such risk while enhancing motor performance in a cohort of 24 adult canines. The study was executed in the form of an experimental pre-test and post-test design, such as 28 elite football players with genetic mutations underwent a six-week structured training program comprising proprioception, agility, and balance drills. Statistically significant differences were found, with 14.32% and 55.90% improvements in agility and balance Z-scores, respectively. Statistical analysis demonstrated significant improvements in motor control, postural stability, and movement efficiency following the intervention (e.g., paired t-test and calculations of effect size). These findings highlight the need to integrate genetic screening with individualized neuromuscular training11 protocols aimed at optimizing athlete performance and injury prevention strategies. Importantly, this study adds to the expanding body of knowledge regarding the translation and utility of empirical data in elite sports, feedback which suggests individualized training regimens are justifiable and necessary. Future research should consider adaptations of long-term training, larger sample size and AI-supported models to predict the risk of injury.