MediGuard is an AI-powered drug interaction checker designed to enhance medication safety by identifying harmful interactions across a broad range of drug classes. The system combines a curated SQLite knowledge base with AI analysis via the Gemini API to deliver real-time results through an intuitive web interface built on Django and Tailwind CSS. In a benchmark evaluation using validated reference data, Medi Guard achieved 95% overall interaction classification accuracy, a mean response time of 2–3 s, and an 89% user-satisfaction score from a pilot study of 50 users. Interactions are graded using explicit criteria aligned with minor, moderate, and severe categories and presented with actionable recommendations. MediGuard targets both healthcare professionals and patients, with safeguards (e.g. confirmation prompts and provenance links) to reduce over-reliance on AI by promoting human oversight.