This chapter surveys the wide range of short-term longevity interventions currently used by health‑conscious individuals and self‑experimenters, focusing on small‑molecule drugs, supplements, thermal stress, oxygen therapy, blood‑based treatments, and stem‑cell‑derived approaches. These interventions—including rapamycin, metformin, NAD⁺ boosters, mitophagy enhancers, GDF11, HBOT, plasma dilution, platelet infusions, and stem‑cell/exosome therapies—can transiently improve biomarkers of aging, enhance mitochondrial function, or reduce senescent cell burden. However, their effects are typically modest, temporary, and limited by biological constraints, side effects, or uncertainties such as mitochondrial haplogroup mismatch. While these methods may offer incremental healthspan benefits, they do not address the fundamental decline in ATP production that drives human aging, underscoring the need for more powerful and durable interventions.